Several months ago, I made a 24-minute video on the benefits of using tianeptine. In the video, I go into detail about all of the aspects of tianeptine.
Here is what I cover in the tianeptine presentation:
- Tianeptine Overview
- Tianeptine Mechanisms of Action
- Tianeptine for Depression
- Tianeptine for Anxiety
- Tianeptine for Irritable Bowel Syndrome (IBS)
- Tianeptine for Acute Opiate Withdrawal
- Tianeptine for Post-Acute Opiate Withdrawal
- Tianeptine for Opioid Cravings
- Recreational Use of Tianeptine
- Tianeptine Abuse
- Tianeptine Addiction
- Tianeptine Dependence
- Tianeptine Withdrawal
- My Experiences Using Tianeptine
- Tianeptine Sulfate vs Tianeptine Sodium
Since this is an opiate recovery blog, I targeted the video to help people on opioid drugs, however, you’ll see from the presentation that it can be watched by and extremely valuable to anyone that wants to learn everything there is to know about tianeptine.
I actually tried to transcribe the entire tianeptine video, but it was taking way too long, so I stopped after 8 minutes. After that, I provide bullet points on the tianeptine slides.
I recommend watching the tianeptine video below as that will be the best way to learn about tianeptine since it has all of the info.
The text below the tianeptine video is there for you to browse over and see an overview of tianeptine. I think it’s helpful to have both resources.
Table of Contents
Tianeptine Video Transcription
So let’s talk a little bit about what this is.
Let’s talk a little about the overview.
I’m going to talk more about what tianeptine is, I’m going to teach you quickly about the pharmacology of tianeptine, I’m going to teach you how it can be used for acute and post-acute opiate withdrawal, how it can be used for pain relief, depression, and anxiety.
Let’s talk a little about the overview of what tianeptine is. Like I said before, tianeptine is an antidepressant medication in many countries. They prescribe it for depression and for anxiety typically.
However, it’s unregulated in the United States, and it’s sold online as a nootropics supplement.
So nootropics are a genre of supplements that actually boost brain performance. They improve cognition. They’re mood-boosters and cognition-enhancers, so that’s what they sell this as, unregulated, online, in America.
Tianeptine Mechanisms of Action
Let’s talk about the mechanisms of action of tianeptine. First of all, tianeptine is a selective serotonin reuptake enhancer. Not a reuptake inhibitor (like Celexa, Paxil, Zoloft, Prozac). It’s not an inhibitor, it’s an enhancer, so it has a little different mechanism of action, but most researchers believe it can increase serotonin.
Serotonin is an inhibitory neurotransmitter that makes you “emotionally relaxed.” Inhibit means “slows down and relaxes” the brain.
So it makes you emotionally relaxed.
That’s why a lot of people can get past symptoms of depression when they’re feeling more emotionally relaxed.
Tianeptine is a tricyclic antidepressant (TCA), which is a specific class of antidepressant that has specific actions.
Tianeptine has an alteration of the glutamate receptor activity. That’s one of the actions.
It also releases brain-derived neurotrophic factor (BDNF). I had just started learning about this recently. When you exercise, you also release BDNF.
What this does, is it actually forces your brain to create new brain cells. I always thought that as soon as you killed your brain cells by taking a bunch of alcohol or drugs or something, that you couldn’t regenerate them.
In fact, you can grow new brain cells, and one of the ways you do that is through BDNF. So tianeptine is a multifaceted medication/nootropic supplement.
It has lots of really cool things and I haven’t even gotten to the main thing that it does.
So it’s an antidepressant, it’s anxiolytic (anti-anxiety), and it’s an analgesic (painkiller).
If it just had those other properties beside being an analgesic, I wouldn’t be as interested in it, and I certainly wouldn’t be trying it out on myself and spending this much time researching it to provide you with this education.
But, along with those other properties, it’s also a full mu- opioid agonist. What that means is when you take hydrocodone, oxycodone, heroin, etc., those are all full mu- opioid agonists. These are drugs that induce opioid pain relief and euphoria.
When you use tianeptine sulfate at dosages above the therapeutic range, that’s when you get the serious opioid agonist effects.
Perhaps you’ve heard of kratom.
Kratom is a natural plant that’s in the coffee family that grows in Southeast Asia. Right now it’s still unregulated in the United States, so it’s selling a lot and it’s helping a lot of people, as kratom is a partial opioid agonist.
Tianeptine activates the opioid receptors in the brain, spinal cord, intestines, and other areas of the body to the full potential, and I’m going to actually tell you about the experiment I did on myself including the different effects I got from the different dosages.
Tianeptine – Conditions it’s Effective For
Here are some conditions that tianeptine has been proven effective for:
- Major Depression
- Panic Disorder
- Depression in Parkinson’s Disease & PTSD
- Irritable Bowel Syndrome
- Pain Syndromes
- Opiate Withdrawal
Tianeptine For Opiate Withdrawal
So let’s talk about opiate withdrawal. Tianeptine is an efficacious mu-opioid agonist (like I spoke of before). Tianeptine binds to the receptors to reduce withdrawal symptoms and cravings.
To develop withdrawal symptoms, that means you first need to develop a dependency to opioids. After you’ve been using opioids for let’s say an average of a couple of months, then all of a sudden, you need a certain concentration of opioids in your blood every single day just to feel normal.
And then, if you taper off opioids too fast, or if you come of opioids cold-turkey, that leads to a net-decrease in blood-opioid concentration, and when that decrease comes down too fast, faster than your body can adjust to the decreases, it induces an opioid withdrawal syndrome. It activates the fight or flight response, and you get extreme fear, anxiety, insomnia, diarrhea, dilated pupils, etc. It’s a horrific experience.
The way that you stop opiate withdrawal obviously is you need to fill up those opioid receptors. A lot of people will do that with the medications Suboxone, Subutex, and methadone. Some people use kratom or tramadol, and tianeptine is just another that kind bind to the receptors and reduces withdrawal symptoms and cravings.
If you take enough it can completely take away withdrawal symptoms, and if you really take enough, tianeptine can actually get you high as a kite, and that was one of my experiences when I experimented with tianeptine.
Here is a recap of tianeptine for opiate withdrawal:
- Efficacious mu-opioid agonist
- Binds to receptors to reduce withdrawal symptoms and cravings
- Highly effective for withdrawal treatment
- Beneficial for Post-Acute Withdrawal Syndrome (PAWS)
- Reduces anxiety, depression, insomnia, and pain
Tianeptine – Continued…
Okay, this article is already over 1100 words and I’m only at the 8-minute mark (out of 24 minutes) as I transcribe the video. Thus, for the remainder of this article, I’m just going to provide bullet points of the slides from the presentation.
Tianeptine For Pain Relief:
- A novel treatment for pain relief
- Unregulated in the U.S. and easily purchased online
- Highly-effective opioid painkiller
- Tolerance, dependence, and withdrawal syndrome if taken daily for a prolonged period of time
Tianeptine Recreational Use and Addiction:
- Gets you super-high at doses above the therapeutic range
- Some people inject large doses IV
- Can cause overdose and death
- Addiction potential
My Experiences using Tianeptine
- 25 mg – Nice, happy, smooth mood-boost
- 50 mg – Nicer, happier mood-boost
- 400 mg – Felt like maybe 40-60 mg of hydrocodone…only better
- 800 mg – So high that I was seriously nodding out and getting itchy and irritated
- Acute Opiate Withdrawal – 100 mg to 400 mg, 3 times a day
- Post-Acute Withdrawal – 25 mg to 50 mg, 1-2 times a day
- Pain Relief – 25 mg to 100 mg, 1-2 times a day
- Depression – 25 mg, 1-2 times a day
- Anxiety – 25 mg, 1-2 times a day
How To Buy Tianeptine Online:
- Tianeptine sulfate form is longer-lasting than tianeptine sodium form.
I hope you enjoyed learning about tianeptine as much as I enjoyed researching and experimenting with it. If you have any comments or questions on tianeptine, please post them in the comment box below.