In this article, I’m going to educate you on the combination of gabapentin and methadone. Many people have gotten mixed answers from doctors and articles on the internet about using gabapentin and methadone together.
Thus, I decided this would be a good subject to write about and end the confusion by bringing clarity to the topic.
So…can you take gabapentin and methadone together?
I’ll answer this question and provide you with reasons to back up my claims that come from:
- Years of Research
- Client Testimonials
- Drug Pharmacology
Most medications have black and white answers when it comes to their combinations. However, with gabapentin and methadone, it’s a gray area.
I’ll do my best to explain this in a simple way that makes sense.
To begin, let’s start with a brief overview of methadone, then I’ll provide an overview of gabapentin.
And after covering the basics on gabapentin and methadone, I’ll teach you about the interactions of these two drugs, and why some doctors say it’s dangerous, while other doctors commonly prescribe the two together.
Table of Contents
Gabapentin and Methadone – Methadone Overview
Methadone is a powerful mu-opioid agonist drug. Methadone binds to the same opioid receptors in the brain and other parts of the body that drugs like heroin, oxycodone, hydrocodone, morphine, and other opioids bind to. Once methadone binds to these receptors, the opioid effects come on.
Common effects of methadone are the same as other opioids:
- Pain Relief
- CNS Depression
- Constricted Pupils
Gabapentin and Methadone – Gabapentin Overview
Gabapentin, sold under the brand names Neurontin among others, is a prescription medication that was designed by chemists at Parke-Davis to be an analog of the neurotransmitter GABA that could more easily cross the blood-brain barrier, thus making the effects in the brain very significant.
GABA is an inhibitory neurotransmitter that acts as a mental relaxant. I often to refer to GABA as the “brain’s natural Valium.”
Gabapentin is commonly prescribed for the treatment of:
- Hot Flashes
- Restless Leg Syndrome
- Neuropathic Pain
Gabapentin is also commonly prescribed for many off-label uses, such as the treatment of:
Gabapentin For Opiate Withdrawal
In addition to gabapentin being useful in the disorders mentioned above, multiple studies have shown significant benefits from using gabapentin for opiate withdrawal.
In fact, whenever I have coaching clients that have consultations with me, I always ask them if they have the ability to get gabapentin as it’s one of my favorite opiate withdrawal medications out of dozens I’ve studied.
Gabapentin and Methadone Taken Together
So now we’ve arrived at the section on using gabapentin and methadone together. To provide you with the best answer, I’m going to quote a passage from what I believe to be the most reliable source on the internet…Drugs.com, which states there is “Moderate” interaction between gabapentin and methadone.
Here is what this authority website states on the combination of gabapentin and methadone:
“Using methadone together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. “
Gabapentin and methadone are both central nervous system (CNS) depressants. Gabapentin and methadone by themselves can both cause respiratory depression and used together, this results in synergy.
Gabapentin/methadone synergy is when the combined effect is greater than the sum of the effects of these two CNS depressants.
When you combine two CNS depressants, in this case, gabapentin and methadone, this significantly increases the chances of respiratory depression and can ultimately lead to death from your body not breathing anymore.
However, it can be safe to use gabapentin and methadone together.
Because your doctor can adjust your doses of medication and frequently monitor you to make sure your body does okay with the combination of gabapentin and methadone.
Now you’ve been educated on the combination of gabapentin and methadone. Again, Drugs.com states that there is a “Moderate” interaction between these two drugs.
The website defines Moderate as:
“Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.”
However, the website also states “Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications.”
As long as you’re under the care of a competent doctor, using gabapentin and methadone together can be totally safe. Always listen to your body and start off with low dosages then work your way up when combining gabapentin and methadone.
If you have any comments or questions on using gabapentin and methadone together, please post them in the comment box below. Take care, and be safe.