Gabapentin (brand name Neurontin) is a gamma-aminobutyric acid (GABA) analogue that was originally developed for the treatment of epilepsy, pain relief and neuropathic pain. Gabapentin was initially synthesized to mimic the chemical structure of the neurotransmitter GABA. Gabapentin is effective in the treatment of social anxiety disorder, panic disorder, and generalized anxiety disorder.
Results with human and rat brain Nuclear magnetic resonance (NMR) spectroscopy indicate that gabapentin increases GABA synthesis, probably by modulating, as it does in-vitro, the action of the GABA synthetic enzyme, glutamic acid decarboxylase and the glutamate synthesizing enzyme, branched-chain amino acid transaminase. Gabapentin is one of the most common medications used on people with alcohol, crack, opioid, and other addictions.